Depends on the field. One of the most influential papers in economics was found to be incorrectly constructed with signs pointing to just straight up fraud. Basically it didn't include data that it said it did, which when included reverses the conclusion. Then when the authors were called out, they doubled down offering up the explanation that the conclusion again reverses if you add a third set of cherry picked data, followed by dragging the person calling them out through the mud in a NY Times opinion piece.

Those authors are still extremely prestigious professors in the field, and have suffered essentially no penalty. https://en.wikipedia.org/wiki/Growth_in_a_Time_of_Debt