My practical view is to avoid spaces in directories and filenames, but to write scripts that handle them just fine (using BASH - I'm guilty of using it when more sane people would be using a proper language).
My ideological view is that unix/POSIX filenames are allowed to use any character except for NULL, so tools should respect that and handle files/dirs correctly.
I suppose for your usage, it'd be better to put the virtualenv directory into your path and then use #!/usr/bin/env python
For the BSDs and Linux, I believe that shebang are intepreted by the kernel directly and not by the shell. /usr/bin/env and /bin/sh are guaranteed by POSIX to exists so your solution is the correct one. Anything else is fragile.
My practical view is to avoid spaces in directories and filenames, but to write scripts that handle them just fine (using BASH - I'm guilty of using it when more sane people would be using a proper language).
My ideological view is that unix/POSIX filenames are allowed to use any character except for NULL, so tools should respect that and handle files/dirs correctly.
I suppose for your usage, it'd be better to put the virtualenv directory into your path and then use #!/usr/bin/env python