Personally I don't think I've ever re-run it. I think I've clicked a few buttons as I've seen alerts about new options appearing. But ultimately it's just a bunch of powershell commands to remove packages and set options. So I'd assume it's safe to run regularly.
Thanks. I was asking because I was hoping to run it for a relative's computer that I am reinstalling Win11 on now, and they would not be capable of re-running it after the fact.
