One definition of potency is how little mass it takes to do its thing, whatever that is. Fentanyl is a potent drug, LSD is a potent psychedelic. That resolves the dichotomy.
There’s a second, softer connotation, of how strong it is in light of whatever other limits may exist. Mescaline is less potent in this way, not just because of the larger mass, but because a dose that’s going to blast you into another realm is going to be much harder on you than some other psychedelics.
Ibogaine (haven’t done it) is very potent by this meaning. Very long, intense trips are possible.
There’s a second, softer connotation, of how strong it is in light of whatever other limits may exist. Mescaline is less potent in this way, not just because of the larger mass, but because a dose that’s going to blast you into another realm is going to be much harder on you than some other psychedelics.
Ibogaine (haven’t done it) is very potent by this meaning. Very long, intense trips are possible.