OP seems to be saying that the logging code has to be in a macro. But it doesn't: it can be in a function that's called by a macro. It's the difference between having the logging code in a macro:

    #define LOG(...)\
        do{\
            if(g_logging_enabled){\
                printf("%s:%d: ",__FILE__,__LINE__);\
                printf(__VA_ARGS__);\
            }\
        }while(0)

And having the logging code in a function called by a macro:

    extern void Log(const char*file,int line,const char*fmt,...);
    #define LOG(...) (g_logging_enabled?Log(__FILE__,__LINE__,__VA_ARGS__):(void)0))

With the Log function being along these lines:

    void Log(const char*file,int line,const char*fmt,...){
        printf("%s:%d: ",file,line);
        va_list v;
        va_start(v,fmt);
        vprintf(fmt,v);
        va_end(v);
    }

(This logging code is deliberately simple; in a realistic system, this would be pages of junk dealing with all manner of log categories, log levels, multiple enable flags and their overrides, log target handling, and whatnot. Absolutely the sort of thing that is 0 fun to keep track of in a macro, even before you consider the fact that it's a ton of code to be pasting everywhere you want to log a string.)