Cartoon History of the Universe is probably the best "nonfiction" comic ever made. (it's not inaccurate but it's kind of psychedelic and retells more than one religious founding text as if it actually happened)
Best part that most people don't realize... There are 3 parts to it... All massive.
I still remember finding part 1 in the used books store with my dad around the age of 10-11 for like $2. Now I'm in my early 30's and all 3 parts are just a handful of books away from my physics and philosophy books on my book shelf :)
I’m a huge fan of the Cartoon History, but I think I’d have to give the prize to Maus for best nonfiction comics. Second runner up would probably be Understanding Comics.
The problem with Understanding Comics is that most comic readers are sensible enough to know that American style comics are bad, so they all read manga instead. Most of the books about that aren’t translated though there is Even a Monkey Can Draw Manga.