none of the models you mentioned are open source...

Doesn't mean they can't be fine-tuned.

https://learn.microsoft.com/en-us/azure/ai-foundry/openai/ho...

Do you think finetuning these LLMS would bring about comparable results to specific models trained for this?

I think so. It feels like there is more to be squeezed from just better prompts but was going to play around with fine-tuning Qwen3

fair enough. I wonder if fine-tuning over different modalities like IMC, H&E etc would help it generalize better across all

Yeah I think one of the things that would be interesting is to see how well it generalizes across tasks. It seems like the existence of pathology foundation models means there is certainly a degree of generalizability (at least across tissues) but I am not too sure yet about generalizability across different modalities (there are some cool biomarker-prediction models though)

going of a tangent but would you say it's worth going to a similarly ranked uni(oxford) if one wants to go into entrepreneurship given its more 'academic' emphasis? as opposed to somewhere like UCSD where it's not as prestigious but close to the tech scene.(bonus points for california weather ha!)

Definitely go to Oxford over UCSD. There’s a world of difference in difficulty to get into, and like the other person says, SD isn’t the biggest tech scene unless biotech is your focus. UC schools are also huge and impersonal, part of what lets them offer decently cheap tuition to in-state students; but if you’re not in-state, I don’t think you’re getting the best value for your money. My answer might change if the alternative were Berkeley.

UCSD is not really near the tech scene, so I wouldn't choose it for that. San Diego is a world away from the Bay Area. The weather in SD is definitely the best in the world, though.

The optimal path for someone in your position is to go to Oxford, then get a job/do a master's at Stanford.

sad to see no neuro-ai , is it too early?

just curious, why are so many predictions so pessimistic?

A lot of people have been having a very bad time these past few years

I would call it "unchained cynicism" more than pessimism.

HN has swung pessimistic for a while now

maybe its naïvety, but I expected a more optimistic/positive outlook from the hacker community lol.

maybe the pessimists are just more likely to comment?

Praying next year is better for you and your family

Merry christmas HN!

a direct messaging system, there've been countless times when I've wanted to ask a poster some (unrelated) questions, but they have no contact details.

yeah scratch, visual basic and swift playgrounds got me into it. Great for piquing interest, especially being able to see projects others built and interact with them.